With low base stats, Esme is instead built around her chance to poison, with her attack bouncing between multiple units and a small AoE if she gets a kill. With how poison functions, this makes her underwhelming against lower-health units. Her Awakenings may seem nice, but do little to help. Esme may be limited against smaller units, but against late-game bosses, her higher base health makes her the best poisoner yet.